Basic Information
VIS ID
TVIS10008734
Fusion event
HBV-LOC109245078 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1894
Orient
+
Integrated sequence
ATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGC| |TTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCT
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69520816/69706048 (Hg38)
End
69520816/69706048 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
LOC109245078
Nearest miRNA
hsa-mir-10392/Upstream/622790; hsa-let-7a-2/Downstream/577907;
Nearest TSS
ENST00000527297/Upstream/1406; ENST00000534086/Downstream/69116;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/887, chr11-CpG: 196/Downstream/68010
Nearby gene
FGF19(-1710) ; FGF4(+66981) ;
Upstream sequence
caagagcccccacagtattctattcctccctcccccatggagcaggagggaaatggccccagaaaagtggccgagtaacccaaggtcgcacactctgtta
Downstream sequence
gtggtgaagttggaatttgaacccaaacagtggggctcgtaaatccaggctGTGCTGCGTCTTATCCCGGGACAGGGGCTCCGGGGTCAGACCCACTGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate