Basic Information
VIS ID
TVIS10008735
Fusion event
HBV-LOC109245078 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2926
Orient
+
Integrated sequence
TTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAA| |CACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCG
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69520876/69706108 (Hg38)
End
69520876/69706108 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
LOC109245078
Nearest miRNA
hsa-mir-10392/Upstream/622850; hsa-let-7a-2/Downstream/577847;
Nearest TSS
ENST00000527297/Upstream/1466; ENST00000534086/Downstream/69056;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/947, chr11-CpG: 196/Downstream/67950
Nearby gene
FGF19(-1770) ; FGF4(+66921) ;
Upstream sequence
agaaaagtggccgagtaacccaaggtcgcacactctgttagtggtgaagttggaatttgaacccaaacagtggggctcgtaaatccaggctGTGCTGCGT
Downstream sequence
CTTATCCCGGGACAGGGGCTCCGGGGTCAGACCCACTGTAGCATGGATCACACCCGGCCACTCCCTGGGTAGGTCGTGGACCGCTGACCCATTGCCCTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate