Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008736
Fusion event
HBV-CHRDL2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
259
Orient
+
Integrated sequence
GAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGT| |GGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAAC
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
Start
End
74424500/74713455 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10392/Upstream/314122; hsa-let-7a-2/Downstream/6813;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/29739, chr11-CpG: 80/Downstream/17760
Upstream sequence
TGGACGATGGGGAGGAGCATGGCTACTTACCCACACACTTGGGACAGCATTGCTGTGGCTCCGTCACAGGCTGGGGGCAGTGGACAGGCGGACAGTGGAG
Downstream sequence
GCGGTAACAACTCACATGGGCGCCCTGAAGGGGACACAAGGGTCAGCCCTGGTTCAAAGAACCATCGTCTTCCACCTGTACCTGTCCTTTCCCAAAACTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.