Basic Information
VIS ID
TVIS10008738
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
119
Orient
+
Integrated sequence
AAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATC| |GTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTG
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
7492997/7471766 (Hg38)
End
7492997/7471766 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/236929; hsa-let-7a-2/Downstream/1618546;
Nearest TSS
ENST00000527297/Upstream/5931; ENST00000534244/Downstream/13622;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/218762, chr11-CpG: 107/Downstream/41557
Nearby gene
SYT9(-2721) ; OLFML1(+13603) ;
Upstream sequence
ccagccCCACTATTCTACTTTCTATCAAGTGCATTCCAAGATAGGCTGACCTTCATGGAAGAAGTGAAATAGAAAACTGAGGAAAAGAAAATAATTGGAA
Downstream sequence
AAAAAGTCCCACAAGTCAAGAAAGTACCCCAAGGAAGACTTACAGGACAACTTCCAAGGCAAATGGGAAAAGAGAACATTGGCAATCTAGGAGCTGCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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