Basic Information
VIS ID
TVIS10008740
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
284
Orient
+
Integrated sequence
GACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGG| |GGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGT
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
87054750/87343708 (Hg38)
End
87054750/87343708 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11F
Nearest miRNA
hsa-mir-10392/Upstream/1065310; hsa-let-7a-2/Downstream/832794;
Nearest TSS
ENST00000527297/Upstream/24641; ENST00000532849/Downstream/375703;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/305657, chr11-CpG: 45/Downstream/831367
Nearby gene
TMEM135(-14874) ; RAB38(+791665) ;
Upstream sequence
gatctgtctaatgttgacagtggggtgttaaagtctcccattattaatgtgtgggagtctaagtctctttgtaggtcactcaggacttgctttatgaatg
Downstream sequence
tgggtgctcctgtattgggtgcataaatatttaggatagttagctcctcttgttgaattgatccctttaccattatgtaatggccttctttgtctctttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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