VISDB Viral Integration Site DataBase

VIS ID

TVIS10008744

Fusion event

HBV-PRKAB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

3067

Orient

+

Integrated sequence

CCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCAT| |ACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCT

Chromosome

chr12

Cytoband

q24.23

Reference genome

Start

End

120116519/119678714 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA12E ; FRA12C

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-148b-3p ; hsa-mir-578 ; hsa-mir-4715-3p ; hsa-mir-4727-5p ; hsa-mir-6780a-3p ; hsa-mir-642a-5p ; hsa-mir-627-3p ; hsa-mir-432-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-2276-5p ; hsa-mir-4469 ; hsa-mir-6892-3p ; hsa-mir-6887-3p ; hsa-mir-6749-3p ; hsa-mir-4713-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-1224-3p ; hsa-mir-665 ; hsa-mir-483-3p ; hsa-mir-4733-3p ; hsa-mir-101-3p

Nearest miRNA

hsa-let-7i/Upstream/3250396; hsa-mir-1178/Downstream/34920;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/10287, chr12-CpG: 31/Downstream/11454

Upstream sequence

tgggatttgtctttctgtgcctggctcatttcacttaatgtcctccaggtttatccatgctgtcacagatgacaagattccttttgtaaggctcagcagc

Downstream sequence

actgcattgtgtatcagtacctcatttctttatccattcatccattgtggacacctacgttgattccacgtcttggctattatgaatagagctgcagtga