Basic Information
VIS ID
TVIS10008749
Fusion event
HBV-LOC105369715 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr12
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
30059772/29906839 (Hg38)
End
30059772/29906839 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369715
Nearest miRNA
hsa-mir-1244-3/Upstream/4032760; hsa-let-7i/Downstream/12416861;
Nearest TSS
ENST00000382841/Upstream/122080; ENST00000549055/Downstream/294144;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/122339, chr12-CpG: 66/Downstream/262991
Nearby gene
TMTC1(-122080) ; IPO8(+722143) ;
Upstream sequence
acgatctcagaatacatacctttcattcgtcgttttccactaagcctctgaaggatgtactccaccaaaataagggagtaaagcaagaaacaaaatacaa
Downstream sequence
agactccagaacagaaagtatctaacacaagtaaaatgcaaagggaatctcaaagatgagggcaaaggcagctgaggccattatcctaagcgaattaaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate