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Viral Integration Site DataBase
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TVIS10008750
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008750
Fusion event
HBV-DENND5B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
485
Orient
+
Integrated sequence
TGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAAT| |TCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCG
Host Sequence
Chromosome
chr12
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
31637311/31484377 (Hg38)
End
31637311/31484377 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND5B
miRNAs that regulate target gene
hsa-mir-1298-5p
;
hsa-mir-20a-5p
;
hsa-mir-106b-5p
;
hsa-mir-8061
;
hsa-mir-4760-5p
;
hsa-mir-548s
;
hsa-mir-3926
;
hsa-mir-4276
;
hsa-mir-2053
;
hsa-mir-569
;
hsa-mir-3152-3p
;
hsa-mir-3650
;
hsa-mir-493-3p
;
hsa-mir-5190
;
hsa-mir-4705
;
hsa-mir-5094
;
hsa-mir-8084
;
hsa-mir-4724-5p
;
hsa-mir-3121-3p
;
hsa-mir-655-3p
;
hsa-mir-429
;
hsa-mir-374c-5p
;
hsa-mir-200c-3p
;
hsa-mir-200b-3p
;
hsa-mir-1304-5p
;
hsa-mir-1238-3p
;
hsa-mir-670-3p
;
hsa-mir-6881-3p
;
hsa-mir-6780a-3p
;
hsa-mir-7111-3p
;
hsa-mir-6086
;
hsa-mir-377-5p
;
hsa-mir-655-5p
;
hsa-mir-1251-5p
;
hsa-mir-329-5p
;
hsa-mir-4538
;
hsa-mir-4453
;
hsa-mir-4284
;
hsa-mir-4772-3p
;
hsa-mir-4638-5p
;
hsa-mir-1307-3p
;
hsa-mir-1304-3p
;
hsa-mir-6741-3p
;
hsa-mir-1914-5p
;
hsa-mir-660-3p
;
hsa-mir-6890-3p
;
hsa-mir-1306-5p
;
hsa-let-7g-3p
;
hsa-let-7a-2-3p
;
hsa-mir-7151-3p
;
hsa-mir-5095
;
hsa-mir-6829-3p
;
hsa-mir-6791-3p
;
hsa-mir-1976
;
hsa-mir-3653-5p
;
hsa-mir-486-5p
;
hsa-mir-6747-3p
;
hsa-mir-6727-3p
;
hsa-mir-4722-3p
;
hsa-mir-4438
;
hsa-mir-4279
;
hsa-mir-122-3p
;
hsa-mir-6833-3p
;
hsa-mir-6873-3p
;
hsa-mir-4768-5p
;
hsa-mir-6868-3p
;
hsa-mir-6853-3p
;
hsa-mir-3182
;
hsa-mir-6817-3p
;
hsa-mir-7110-3p
;
hsa-mir-1248
;
hsa-mir-1237-3p
;
hsa-mir-4290
;
hsa-mir-4740-3p
;
hsa-mir-4687-5p
;
hsa-mir-449b-3p
;
hsa-mir-6856-3p
;
hsa-mir-8485
;
hsa-mir-4662a-5p
;
hsa-mir-582-5p
;
hsa-mir-600
;
hsa-mir-323b-3p
;
hsa-mir-708-3p
;
hsa-mir-144-3p
;
hsa-mir-101-3p
;
hsa-mir-93-5p
;
hsa-mir-519d-3p
;
hsa-mir-20b-5p
;
hsa-mir-17-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/5610298; hsa-let-7i/Downstream/10839323;
Nearest TSS
ENST00000382841/Upstream/57626;
ENST00000536397/Downstream/11525;
Nearest CpG islands
None/Target,
chr12-CpG: 104/Upstream/157929
,
chr12-CpG: 202/Downstream/105449
Upstream sequence
tttgaaaaggagatggcagccttggagatgagaagcatagtggctggccatcagaagttgacaatgatcaattgagagtaatcactgaagctgaccctct
Downstream sequence
tcagcaacatgaaaagttgctgaagaactcaacgtcgaccattctatggccgtttgacatgtgaagcaaattggaaaggtggaaaaactcggtaagtggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Sample Information
×
Sample name
712P
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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