Basic Information
VIS ID
TVIS10008755
Fusion event
HBV-LOC105369818 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
68655486/68261706 (Hg38)
End
68655486/68261706 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105369818
Nearest miRNA
hsa-let-7i/Upstream/2010549; hsa-mir-1178/Downstream/1011451;
Nearest TSS
ENST00000382841/Upstream/8099; ENST00000544089/Downstream/33617;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/611610, chr12-CpG: 54/Downstream/70361
Nearby gene
IL22(-8205) ; MDM1(+32860) ;
Upstream sequence
GTTCTTGACTTAAAATCTTAGCATGAGTCTCCTTTTGCCTTCATCCTGTATGGTCAAACTGTCCTAAACCCTCCTGTGTCTTCCTTTGAAATATCTCTTT
Downstream sequence
ATGTAGAATCTTTTCCTCTTTCAATCAATAAATATCTACTGACACTTTCTATTTTTGGAACCACTACGAGTGAGTTGTTGTCAAAAATAATCCCAGAaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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