VISDB Viral Integration Site DataBase

VIS ID

TVIS10008757

Fusion event

HBV-MGAT4C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1828

Orient

+

Integrated sequence

AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT

Chromosome

chr12

Cytoband

q21.32

Reference genome

Start

End

86989062/86595285 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-5584-5p ; hsa-mir-607 ; hsa-mir-1277-5p ; hsa-mir-496 ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-5p ; hsa-mir-5011-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-4789-3p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4797-5p ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3614-3p ; hsa-mir-1287-3p

Nearest miRNA

hsa-let-7i/Upstream/5436824; hsa-mir-1178/Downstream/149783;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/1314363, chr12-CpG: 52/Downstream/1440043

Upstream sequence

attactctttaagtagcaaggTTTGGTTCATCCTTAAAAACCTAAATAACCGTTCTTTTAAAACTGATCATCTATTggccaggttcggtggctcatgcct

Downstream sequence

gtaatcccagcactttgggaggataacctgaggtcaggagttcgagaccagcctggccaacatgctgaaacaccatctctactaaaaatacaaaaattag