Basic Information
VIS ID
TVIS10008758
Fusion event
HBV-LOC105369890 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1822
Orient
-
Integrated sequence
GTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAA
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
90488016/90094239 (Hg38)
End
90488016/90094239 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC105369890
Nearest miRNA
hsa-let-7i/Upstream/3349090; hsa-mir-1178/Downstream/4467550;
Nearest TSS
ENST00000382841/Upstream/146546; ENST00000548722/Downstream/13500;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/383951, chr12-CpG: 30/Downstream/859788
Nearby gene
ATP2B1-AS1(-382287) ; LINC00615(+823784) ;
Upstream sequence
aaatatatattatatataaaaatatttaatatatatatttatataaAGACAAATGGCTAAACTGTTTAATATGGCCAGCATGGTCTTGTAGAGGATGAGC
Downstream sequence
TATTTACAATTGAGTGAACCCTTAAGCTTAAGTACTCTAAAACCCTATATATTAATCTATCATAGTAGTTTTCACAGTATTATAAAGGTATATTTAGTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate