Basic Information
VIS ID
TVIS10008760
Fusion event
HBV-GGACT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2125
Orient
+
Integrated sequence
TTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTA| |ATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCT
Host Sequence
Chromosome
chr13
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
101211542/100559288 (Hg38)
End
101211542/100559288 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
GGACT
miRNAs that regulate target gene
hsa-mir-5191 ; hsa-mir-3907 ; hsa-mir-4790-3p ; hsa-mir-521
Nearest miRNA
hsa-mir-1297/Upstream/916139; hsa-mir-1267/Downstream/1408354;
Nearest TSS
ENST00000623511/Upstream/21923; ENST00000457843/Downstream/24709;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/26694, chr13-CpG: 71/Downstream/29147
Upstream sequence
ATTCATTAATTCAtttttgagacggagtctcatctgttgcccaggctggagtgcaatgacacaatcttggctcactgcaacctccgcctccctggctcaa
Downstream sequence
gcgattctcctgcctcagcctctcgagtagctgggattacaggcatgtgccaccatgtccagctaatttttgtatttttagtagaatagggtttcaccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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