Basic Information
VIS ID
TVIS10008775
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2334
Orient
+
Integrated sequence
AAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCG| |GAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAAT
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
66463731/65997013 (Hg38)
End
66463731/65997013 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA14B
Nearest miRNA
hsa-mir-208a/Upstream/525827; hsa-mir-1185-1/Downstream/1444842;
Nearest TSS
ENST00000550708/Upstream/360496; ENST00000556662/Downstream/7510;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/583361, chr14-CpG: 40/Downstream/16602
Nearby gene
FUT8(-252892) ; OLMALINC(+489378) ;
Upstream sequence
ccgggagcccattagagacggagaatcgaggccccctcccaggccttctcaatcagattctgcattttaattactttcctaggtgttaaatatgcacaat
Downstream sequence
aatgttggagaagcaGCCCAGTGAttttctttctttttttttttttttgagacagagtctcactctgtcgcccaggctggagtgcagtggcgcaatctcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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