Basic Information
VIS ID
TVIS10008778
Fusion event
HBV-UNC79 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2110
Orient
+
Integrated sequence
CTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTA| |CCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTT
Host Sequence
Chromosome
chr14
Cytoband
q32.12
Reference genome
GRCh37/hg19
Start
93816865/93350519 (Hg38)
End
93816865/93350519 (Hg38)
Orient
-
Location type
Intronic
Target gene
UNC79
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-1260a/Upstream/16084229; hsa-mir-1185-1/Downstream/597707;
Nearest TSS
ENST00000550708/Upstream/3328; ENST00000555664/Downstream/79818;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2754, chr14-CpG: 45/Downstream/79952
Upstream sequence
aataactggttatttttaaaaagaactgtaatgtaagacaagtaagaaagtaaaaaatgttataaatgggctgtgtaagtggttataaggtataagaaac
Downstream sequence
agaatttataaaaggaacgttgtaagtaattaagttggttataattaaaaaggaaaccattataatagtctttctaaaggttagccccttacattaaaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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