Basic Information
VIS ID
TVIS10008780
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2180
Orient
-
Integrated sequence
TTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATAT| |GGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATT
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
GRCh37/hg19
Start
27020320/26775173 (Hg38)
End
27020320/26775173 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1268a/Upstream/926348; hsa-mir-10393/Downstream/1651318;
Nearest TSS
ENST00000557528/Upstream/1170; ENST00000555060/Downstream/15127;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1300, chr15-CpG: 17/Downstream/63672
Nearby gene
GABRB3(-1385) ; GABRA5(+91546) ;
Upstream sequence
GCTTTATCACCCCAGCTGCTGCCTCAGCACCCAGTTCTGCAAGAGGTCTGATCAGCTTTACATGGGAACAAGCCCACATGGGATATGATCACCTCATATC
Downstream sequence
CGCAAGGTCTGAGATGCCACGGGATTTGCTCAGTACTCACATATATGCAATCTGAAATTTCAGGCAAGTTAGAAGTCTATGAGGCAGACTTTTGTCTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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