MAP2K5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008784
Fusion event
HBV-MAP2K5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
4
Orient
-
Integrated sequence
AATT| |CCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTAC
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
68022339/67730001 (Hg38)
End
68022339/67730001 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAP2K5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-214-3p ; hsa-mir-330-3p
Nearest miRNA
hsa-mir-10393/Upstream/1232967; hsa-mir-11181/Downstream/1071849;
Nearest TSS
ENST00000557528/Upstream/12004; ENST00000558021/Downstream/18367;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/186829, chr15-CpG: 29/Downstream/90902
Upstream sequence
TCAAGTGGAAGTTGGAAAATTCTAATACTATGCTGAACTCCCTAGTTAGCAACAACCTTTATACCAGAGTTGGGGCGGGAAACAACTGTATTCCTTGAAT
Downstream sequence
CATGATAGAATGTTGTCACCAAATTGTTACTTCTATCTGAAATAATAGAAGCAGCTTTGATGCCGTTAGGCCTATTTCCTAAGTTTTTCAACAGAAGTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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