Basic Information
VIS ID
TVIS10008786
Fusion event
HBV-MIR4514 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
81288985/80996644 (Hg38)
End
81288985/80996644 (Hg38)
Orient
-
Location type
downstream
Target gene
MIR4514
Nearest miRNA
hsa-mir-10393/Upstream/154571; hsa-mir-11181/Downstream/773;
Nearest TSS
ENST00000557528/Upstream/3386; ENST00000267984/Downstream/3337;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/6568, chr15-CpG: 300/Downstream/3808
Upstream sequence
gggaggctaaggtgagaggaccacttgaggccaagggtgtgagaccagtctggatatcaaagtgagactgtgtctctGAGACTTTCTCGCTACtaaataa
Downstream sequence
ataaataaataaatTTTTGATAGAATGAAAAGATCCGGAGTGCTtacaatggaataccgttcacccataaaaaagaagggaaattcccatgtatgctata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate