Basic Information
VIS ID
TVIS10008790
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
484
Orient
+
Integrated sequence
CTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAA| |TTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTC
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
32904145/32892824 (Hg38)
End
32904145/32892824 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/1998839; hsa-mir-11401/Downstream/1270754;
Nearest TSS
ENST00000527434/Upstream/6367; ENST00000565463/Downstream/10618;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6323, chr16-CpG: 32/Downstream/32611
Nearby gene
SLC6A10P(-7682) ; TP53TG3(+301440) ;
Upstream sequence
gagaatggaaccaagttggaaaacactcttcatgatagtatccaggagaacctctgcaacctagcaaggaaagtaaacattcaaattctggaaatacaga
Downstream sequence
gaacaccacaaagatactcgctgagaagagcaaccctaagacacataattgtcagattcaccaaggttgaaatgaaggagaaagttttaagggcaaccag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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