Basic Information
VIS ID
TVIS10008792
Fusion event
HBV-LOC105369183 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
348
Orient
+
Integrated sequence
TCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCT| |TGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTC
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
33771058/33968591 (Hg38)
End
33771058/33968591 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369183
Nearest miRNA
hsa-mir-1225/Upstream/3074606; hsa-mir-11401/Downstream/194987;
Nearest TSS
ENST00000527434/Upstream/29792; ENST00000319817/Downstream/6492;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/40199, chr16-CpG: 164/Downstream/6588
Nearby gene
RNU6-76P(-207815) ; LINC00273(+189994) ;
Upstream sequence
TCAAAGGTCACCTTTGATGTGTTACTGGAGGCAGAATTCTGACCTTATTACATGTAGGTGGCACATCTGACATAAATAAACAGGCAAGAAAACAGAGAAA
Downstream sequence
GGACCTGGCACAACACTGTGCCATGGCACAActctggttgcccttaaaactttctccttcatttcaaccttggtgaatctgacaattatgtgtcttaggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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