Basic Information
VIS ID
TVIS10008793
Fusion event
HBV-LOC105371308 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
63593996/63560092 (Hg38)
End
63593996/63560092 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105371308
Nearest miRNA
hsa-mir-1225/Upstream/5787740; hsa-mir-11401/Downstream/3642229;
Nearest TSS
ENST00000527434/Upstream/191248; ENST00000563061/Downstream/57952;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1523362, chr16-CpG: 19/Downstream/1390686
Nearby gene
CDH8(-1523257) ; CDH11(+1386687) ;
Upstream sequence
TGGATGCTCAAATGAATTTGATCATTCACTATATAATTTTCAATATGATCTCTGCTTCAATACCCTATTTTACACTCTTGTAATTGGGGAGAAGGGAAAT
Downstream sequence
CACGTAGTTTGAAAAGTGCACTGCATTTGTAGtaaataaataaataaataagtacgtaaattaaaaaataaagaaaAACTGTACATTCTATTCAacttac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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