Basic Information
VIS ID
TVIS10008795
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1461
Orient
-
Integrated sequence
TATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACC| |CTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCC
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67674887/67640984 (Hg38)
End
67674887/67640984 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA16B
Nearest miRNA
hsa-mir-1225/Upstream/438589; hsa-mir-11401/Downstream/592442;
Nearest TSS
ENST00000527434/Upstream/14475; ENST00000602467/Downstream/3935;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/77333, chr16-CpG: 54/Downstream/3705
Nearby gene
CTCF(-1799) ; CARMIL2(+4143) ;
Nearest cancer related gene
CTCF(TSG, -1799) ;
Upstream sequence
atgggccatgccatcacacctggctcatttttgttttttttgtttttttagggtttttttttttttttttttttttagagataggatcttgctatgttgc
Downstream sequence
ccaggctagtctcaaactcctggactgaagtgatcttcctgcctcagcctccaaaagtgctggattataggcatgaaccaccattcccagccACCTAAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate