VISDB Viral Integration Site DataBase

VIS ID

TVIS10008806

Fusion event

HBV-NF1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1770

Orient

-

Integrated sequence

GACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTT| |TGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAG

Chromosome

chr17

Cytoband

q11.2

Reference genome

Start

End

29626019/31299001 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-370-3p ; hsa-mir-20a-3p ; hsa-mir-193b-3p ; hsa-let-7e-5p ; hsa-mir-9-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-193a-3p ; hsa-mir-374a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-107 ; hsa-mir-514a-5p

Nearest miRNA

hsa-mir-1180/Upstream/204576; hsa-mir-10226/Downstream/235882;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/203541, chr17-CpG: 29/Downstream/46316

Nearest cancer related gene

NF1(TSG, No orient, 0)

Upstream sequence

AGTGTAGAAGTAGAGTTATGCATTTTCATTACACTTAACAGTACTTTTGTTTGAAAGAAAAGACATGTTACTTCATTAATGGATTCAAATGAATTTGGGT

Downstream sequence

TTAGGCTGTATCAAGTTTAGTTTCTGTTGTATATAATAGAAAATTCCAGTGCAATAGTAGTGGCAATGTTTCTCATTTCAAGTTTGGGACATACCAAATT