VISDB Viral Integration Site DataBase

VIS ID

TVIS10008807

Fusion event

HBV-NF1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1815

Orient

+

Integrated sequence

ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC

Chromosome

chr17

Cytoband

q11.2

Reference genome

Start

End

29626066/31299048 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-10b-5p ; hsa-mir-370-3p ; hsa-mir-20a-3p ; hsa-mir-193b-3p ; hsa-let-7e-5p ; hsa-mir-9-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-193a-3p ; hsa-mir-374a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-107 ; hsa-mir-514a-5p

Nearest miRNA

hsa-mir-1180/Upstream/204623; hsa-mir-10226/Downstream/235835;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/203588, chr17-CpG: 29/Downstream/46269

Nearest cancer related gene

NF1(TSG, No orient, 0)

Upstream sequence

TGTTTGAAAGAAAAGACATGTTACTTCATTAATGGATTCAAATGAATTTGGGTTTAGGCTGTATCAAGTTTAGTTTCTGTTGTATATAATAGAAAATTCC

Downstream sequence

AGTGCAATAGTAGTGGCAATGTTTCTCATTTCAAGTTTGGGACATACCAAATTGCTTCATATTATTCAAAGATTATTGTAAAATTCTCAAAAAGAAAAAG