Basic Information
VIS ID
TVIS10008814
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1785
Orient
-
Integrated sequence
CAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTG| |TAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
6618681/6715362 (Hg38)
End
6618681/6715362 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1253/Upstream/59853; hsa-mir-10226/Downstream/302253;
Nearest TSS
ENST00000595228/Upstream/1795; ENST00000575267/Downstream/40085;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/1210, chr17-CpG: 49/Downstream/60524
Nearby gene
XAF1(+40475) ;
Nearest cancer related gene
XAF1(TSG, +40475) ;
Upstream sequence
aaatatatgacacattattatGATGTAATTTCTATTTACTGTCTGTTTTATTCATCACCACCTGTCCAGCTAGTGCCTTTCTCAGTGCCTAATCCAGGAT
Downstream sequence
GTGCACTCAAACCTTTTTCTCCGGGATGCATGAATGAGAGCAAGTAAACAACTTCAGTTCTTTTTTCTTttctttttttttaattttactttaagttctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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