VISDB Viral Integration Site DataBase

VIS ID

TVIS10008826

Fusion event

HBV-DCC integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

120

Orient

+

Integrated sequence

AACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCG| |TCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGT

Chromosome

chr18

Cytoband

q21.2

Reference genome

Start

End

50750797/53224427 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-889-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4696 ; hsa-mir-6500-3p ; hsa-mir-5092 ; hsa-mir-1255b-2-3p ; hsa-mir-6738-3p ; hsa-mir-3678-3p ; hsa-mir-544a ; hsa-mir-513b-5p ; hsa-mir-2467-3p ; hsa-mir-298 ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-6847-5p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-219a-2-3p

Nearest miRNA

hsa-mir-1-2/Upstream/3097864; hsa-mir-122/Downstream/12674;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/882075, chr18-CpG: 59/Downstream/999972

Nearest cancer related gene

DCC(TSG, No orient, 0)

Upstream sequence

tatctttgcatgactgtgaagctgaaatgagaatagaatagaagacggattgctgggttccggccagatctggcggggctttgtagggtgtgataaaagt

Downstream sequence

tgggatttcattctatggacaatgaaaagcatattgaaaggagagtaatcagattcaccttttttaagaattacactgactactgtgggaaaattatcag