Basic Information
VIS ID
TVIS10008828
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1784
Orient
-
Integrated sequence
TCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCT| |GTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGC
Host Sequence
Chromosome
chr18
Cytoband
q22.2
Reference genome
End
68004903/70337667 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-1-2/Upstream/3255981; hsa-mir-548av/Downstream/2515654;
Nearby gene
SOCS6(-7469) ; LINC01541(+1182297) ;
Upstream sequence
GCAATATTGTCAAACAACTTCTACAAAGTAAGCAAAAATGGAGTAACTAGAAGTAGCAGAGGAGAGAAATATCATAAATATGTTAAGCATTGAGAGTTAG
Downstream sequence
CTAGGGTTGTCAGCAAATAAAACTTTTTGTTTGTTAATATGGCATGCTATAACTCTTTCAAAATAACGTAAGTGGCTTGAAATAAAGTCTACATAAGCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate