Basic Information
VIS ID
TVIS10008829
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
69843357/72176122 (Hg38)
End
69843357/72176122 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/5094436; hsa-mir-548av/Downstream/677199;
Nearest TSS
ENST00000575820/Upstream/231545; ENST00000578967/Downstream/364176;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1745262, chr18-CpG: 225/Downstream/365617
Nearby gene
LINC01541(-597165) ; CBLN2(+360558) ;
Upstream sequence
GGAAATTATAGGTCAGGGTATCCTTTTGTTCTTTACATTAAAATATCAGATTCCTTAGGGGTTCATTACTGTCCCATCTTTTtccctaggtaatctccta
Downstream sequence
ggaatacattcccacaattaaattctaagaatatgctaatagaatactaattcatttgaagcctcttcctctaactttcatgagtcatacttccaccacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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