Basic Information
VIS ID
TVIS10008830
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2550
Orient
+
Integrated sequence
TTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAA| |TATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGG
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
69843365/72176130 (Hg38)
End
69843365/72176130 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/5094444; hsa-mir-548av/Downstream/677191;
Nearest TSS
ENST00000575820/Upstream/231553; ENST00000578967/Downstream/364168;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1745270, chr18-CpG: 225/Downstream/365609
Nearby gene
LINC01541(-597173) ; CBLN2(+360550) ;
Upstream sequence
TAGGTCAGGGTATCCTTTTGTTCTTTACATTAAAATATCAGATTCCTTAGGGGTTCATTACTGTCCCATCTTTTtccctaggtaatctcctaggaataca
Downstream sequence
ttcccacaattaaattctaagaatatgctaatagaatactaattcatttgaagcctcttcctctaactttcatgagtcatacttccaccacctcactgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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