Basic Information
VIS ID
TVIS10008839
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|
Start
1250
Orient
-
Integrated sequence
CGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTT| |TCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCC
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
End
58314820/57803452 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-let-7e/Upstream/2415210; hsa-mir-10394/Downstream/531236;
Nearby gene
ZNF586(-22836) ; ZNF552(+3630) ;
Upstream sequence
catacattcccttttatagcttttcttacgactttcacaatcttcaacatgtcttaactttctgccttccttttacactatttttttcctaGTTTCACCT
Downstream sequence
CCTTTGTCTTCTTTTGAtttctgtctcttccagtttctctcttactctttccttctatttctttctctcatttgcactctattttccgctctctcatccc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate