Basic Information
VIS ID
TVIS10008847
Fusion event
HBV-TEX41 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1802
Orient
-
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
145458662/144701095 (Hg38)
End
145458662/144701095 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA2S ; FRA2K
Target gene
TEX41
Nearest miRNA
hsa-mir-128-1/Upstream/4114410; hsa-mir-10b/Downstream/4629183;
Nearest TSS
ENST00000437798/Upstream/10031; ENST00000614173/Downstream/7101;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/176607, chr2-CpG: 49/Downstream/1886138
Upstream sequence
TTAGTCACCATTTTatttatttatacaataaatgcttaccaactatctaatctgggccaatttctgtgccaggaattggggttaacagagaagtataaga
Downstream sequence
tttggtccttggcctaaagcagttcacagcctggagggcagagatacataaataaaagatgagaggtattattacaagagcatggtcccaaactataaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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