VISDB Viral Integration Site DataBase

VIS ID

TVIS10008848

Fusion event

HBV-COBLL1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2451

Orient

+

Integrated sequence

ACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGT| |TAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAAT

Chromosome

chr2

Cytoband

q24.3

Reference genome

Start

End

165572549/164716039 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-3943 ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-6793-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-4424 ; hsa-mir-627-3p ; hsa-mir-6768-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-600 ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-4694-3p

Nearest miRNA

hsa-mir-128-1/Upstream/4308157; hsa-mir-10b/Downstream/3866904;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/94207, chr2-CpG: 145/Downstream/124921

Upstream sequence

CACCAAATGTGCCAAATGAAAAATTCTCCAAAAGGTTCTGTGAATTCTATGGGTCAAGATTACCAAATACTTTTCCCTGACTCTTCTTCCACTTATTCAA

Downstream sequence

ATGTAAAATCAGCTTATGAGGCTAATTTGTCAATAAGACCAGAACATCCTTTGGCCATTGATTTTATTAAATGTGCTCTTCATAAACTCTTGGTCAGCAG