Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008852
Fusion event
HBV-ITGA4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2379
Orient
+
Integrated sequence
TCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGA| |ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGG
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
End
182383649/181518922 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/213270; hsa-mir-1244-1/Downstream/2860053;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/60620, chr2-CpG: 65/Downstream/137572
Upstream sequence
ttaaaaataGTGCCTGATAGTATATTTTGTTTTTTAAACATAGTTTGTCAATATAACTTAGGCTGGTTGTGAAAGTAAGCCAAGATTCAAAGATTTTTAA
Downstream sequence
GAAATTAATCCTCAGTTAAAAAATTATAAGAATCTCTCCTAGATAGAAACAAAGATAGATATAAATATGTATCTAGCCTACAGAATTACGTGTGTATGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.