Basic Information
VIS ID
TVIS10008855
Fusion event
HBV-LINC01821 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
740
Orient
+
Integrated sequence
TATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTAT| |ATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACC
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
195231950/194367226 (Hg38)
End
195231950/194367226 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01821
Nearest miRNA
hsa-mir-10b/Upstream/5234115; hsa-mir-1244-1/Downstream/12416008;
Nearest TSS
ENST00000437798/Upstream/22944; ENST00000447194/Downstream/363369;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2171140, chr2-CpG: 150/Downstream/1289605
Nearby gene
PCGEM1(-1590325) ; SLC39A10(+1289582) ;
Upstream sequence
aattgaaaataaaaTACTGGTAGAAAAATTTACAAAGCATGtgttggggtgatcagacccaacaccagaccgtgggggctacgaagtccggcagagtcaa
Downstream sequence
aggaatgagataagacaagttaaggtgtaaagtgggaccgggggccaacgctagtatggaggctgcaaaggcccagagctctggaagcccacactatttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate