Basic Information
VIS ID
TVIS10008857
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2870
Orient
+
Integrated sequence
GGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACC| |AGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCT
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
199909738/199045015 (Hg38)
End
199909738/199045015 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/9911904; hsa-mir-1244-1/Downstream/7738219;
Nearest TSS
ENST00000437798/Upstream/272659; ENST00000489557/Downstream/26776;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1239585, chr2-CpG: 315/Downstream/410764
Nearby gene
PLCL1(-895130) ; SATB2(+224485) ;
Upstream sequence
atgtacgattcgcgaatcaggcagcccccagaatcacagcagattcacagagactccaggggtccatggtcagaacaaatttatcgacaaaaaaggtaaa
Downstream sequence
gtgacatacaagaatcagaaggaaggtagagaaacagtgggattggttcaacgttcaaataaggaaaagctcaacgtttgccttatttgaacacggtttg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate