Basic Information
VIS ID
TVIS10008858
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1994
Orient
+
Integrated sequence
TTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCT| |AGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAA
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
208190380/207325656 (Hg38)
End
208190380/207325656 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/56232; hsa-mir-1244-1/Downstream/429151;
Nearest TSS
ENST00000437798/Upstream/65211; ENST00000414681/Downstream/204081;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/158903, chr2-CpG: 174/Downstream/203575
Nearby gene
KLF7(-158410) ; CREB1(+204236) ;
Nearest cancer related gene
CREB1(OG, +204236) ;
Upstream sequence
ttgaactagagctaatgggaaataaattcttaagcctctttttggttgcacttacctcttgaaagcatttgttattattttcttgtactcttttgcatgt
Downstream sequence
ggttttgaaatatgtgcaatgatatatcaagttatttttccaacaagccaagaaaattacctgttggaaaagagtaaaaaactcaataattaagccagtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate