Basic Information
VIS ID
TVIS10008859
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1446
Orient
-
Integrated sequence
GTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGA| |ATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGA
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
208195344/207330620 (Hg38)
End
208195344/207330620 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/61196; hsa-mir-1244-1/Downstream/424187;
Nearest TSS
ENST00000437798/Upstream/70175; ENST00000414681/Downstream/199117;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/163867, chr2-CpG: 174/Downstream/198611
Nearby gene
KLF7(-163374) ; CREB1(+199272) ;
Nearest cancer related gene
CREB1(OG, +199272) ;
Upstream sequence
TCCATTGGGCAATGTGCTTAGCAACTTGCACATTAAGCCTTCTATTAAGATTATATTAATATCATAAATATGCAAAAAGGAAACCACTCTGAAAGTTCAA
Downstream sequence
AATAATAACAATAACCTTTCCCTCAAGTAAAACCTTTTATCTTGAGATCTCTATGCACTTTCCCAACAAGCCTGAGTATCCTTGCCCAGCCACTTTTGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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