ADCY3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008873
Fusion event
HBV-ADCY3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3122
Orient
+
Integrated sequence
ACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGA| |AGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25121394/24898525 (Hg38)
End
25121394/24898525 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCY3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1301-3p ; hsa-mir-1296-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-3125/Upstream/5550020; hsa-mir-10b/Downstream/430115;
Nearest TSS
ENST00000437798/Upstream/20498; ENST00000421904/Downstream/20661;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/104767, chr2-CpG: 129/Downstream/21078
Upstream sequence
TCGGGGAGAGGGGCTTCGTGTACTTCACACAGTGCTTCATGAAGGGGTGAGTCAGGCGCCATCTCTCCTTTTTCCAAAAGGAAAAATGAGCCACACCACA
Downstream sequence
GATTAAGTCAATTACACTCAGCCAGAGGAAATATCCTCCGAAGATCTTCACTCTCAAATCAGCCTCTCAATGGAGCCCTGCAGCACTGGAAAGGAGCCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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