Basic Information
VIS ID
TVIS10008876
Fusion event
HBV-LOC105374378 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1742
Orient
-
Integrated sequence
CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT| |TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
27941737/27718870 (Hg38)
End
27941737/27718870 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374378
Nearest miRNA
hsa-mir-1301/Upstream/2390149; hsa-mir-10b/Downstream/277497;
Nearest TSS
ENST00000437798/Upstream/3138; ENST00000472192/Downstream/52847;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3116, chr2-CpG: 48/Downstream/16470
Nearby gene
SLC4A1AP(-23890) ; MRPL33(+52847) ;
Upstream sequence
cagactggagtgcattggtgcaatatcagctcactgcaacctccacctcctgggtttaagagattcagctgcctcagcctcctgagtagcttggactaca
Downstream sequence
ggtgcatgccaccacgcccagctaatttttgtatttttagtagagatggggtttcaccatgttggccagtctggtcttgaactcctgacctcaggtgatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate