Basic Information
VIS ID
TVIS10008881
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
667
Orient
-
Integrated sequence
TGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCT| |CCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAG
Host Sequence
Chromosome
chr2
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
53500647/53273509 (Hg38)
End
53500647/53273509 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Nearest miRNA
hsa-mir-1301/Upstream/570894; hsa-mir-10b/Downstream/575613;
Nearest TSS
ENST00000437798/Upstream/363489; ENST00000295304/Downstream/332569;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/643523, chr2-CpG: 28/Downstream/494245
Nearby gene
ASB3(+396470) ;
Upstream sequence
atgtaacaaacctgcacatggacccctgaacttaaaataaaagttaaaaagaaGAGTGGAAAGGAAAGCTAAAAAGAGGGGCACATCACCATCATACAAA
Downstream sequence
GTTTACAAGGAGTCCAGATATAATATATATAGTTGATGAGACAAGAAGTTTAATTACTTAAATTATATTTACAAACACAGCCAAGAGAGAAACTTAATGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate