Basic Information
VIS ID
TVIS10008882
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1804
Orient
-
Integrated sequence
ATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGC| |GCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
58624654/58397519 (Hg38)
End
58624654/58397519 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/2396724; hsa-mir-10b/Downstream/1989843;
Nearest TSS
ENST00000437798/Upstream/121642; ENST00000455219/Downstream/30280;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/156022, chr2-CpG: 71/Downstream/30789
Nearby gene
FANCL(-156139) ;
Upstream sequence
AGGTATCCTAACTTACCCTTCTTCTGAAAGCAACTAAATGCTAAGCAATTCTTTTTTAACTCCTTAAGTGCATTAATAATATGACTACAAGACAAATAAA
Downstream sequence
AAACTAAGTGAAGTCAAGATTCCAGAAGTGTTTCTATGTAAGAGAATAAGAGTAAGTTAGAAACAAGCCAGATTCCTTCCTCCCTGCACCCCACATTCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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