VISDB Viral Integration Site DataBase

VIS ID

TVIS10008890

Fusion event

HBV-PLCB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2449

Orient

+

Integrated sequence

AGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAAT| |GTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTA

Chromosome

chr20

Cytoband

p12.3

Reference genome

Start

End

8468846/8488199 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-423-5p ; hsa-mir-30c-5p ; hsa-mir-297 ; hsa-mir-4325 ; hsa-mir-6867-5p ; hsa-mir-567 ; hsa-mir-223-5p ; hsa-mir-3607-5p ; hsa-mir-511-3p ; hsa-mir-502-3p ; hsa-mir-501-3p

Nearest miRNA

hsa-mir-103a-2/Upstream/1116507; hsa-mir-1-1/Downstream/2161437;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/355254, chr20-CpG: 107/Downstream/580112

Upstream sequence

AGTTCAATACATTTTGATATGTTGTTATGATGAAGAAACATGAAAATTCTAAAAATGCCCATTTGTTGATTACAGAGCAATTAAGTTTTAAATGATTCAA

Downstream sequence

GTGAGTCTAGGAATGTAAATCTTAACCATTGCAGAAGTGAATTAAACATGTTTAGAGAAATCACAATTAGTCAAAAAAGGTAAGGTAGATTATTCTACCT