Basic Information
VIS ID
TVIS10008894
Fusion event
HBV-NIPA2P3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
433
Orient
-
Integrated sequence
CACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCT| |TCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGAC
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
21001765/19629451 (Hg38)
End
21001765/19629451 (Hg38)
Orient
+
Location type
Intronic
Target gene
NIPA2P3
Nearest miRNA
hsa-let-7c/Upstream/943287; hsa-mir-155/Downstream/3449833;
Nearest TSS
ENST00000624081/Upstream/327838; ENST00000486367/Downstream/270304;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1383894, chr21-CpG: 89/Downstream/1367654
Nearby gene
TMPRSS15(-1225795) ; LINC00320(+1113148) ;
Upstream sequence
gaggcaaagctgcccaaggccatgggatccaccctttgaatcagcatgccctggatgtgagacgtggagccaaagaagattatttcagagttttaagatt
Downstream sequence
ccatgactgccccactaaattttggactagtatggggcctgtagcccctttgttttggccaatttctcccatttgaaatggcatgatttactcaatgaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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