Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008896
Fusion event
HBV-RWDD2B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2433
Orient
+
Integrated sequence
GGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAA| |TCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAA
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
Start
End
30381217/29008896 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-let-7c/Upstream/2054853; hsa-mir-3197/Downstream/1366398;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/5989, chr21-CpG: 44/Downstream/10047
Upstream sequence
ACCAGCCTGAGCAACATACTGAGACCATCTATAAAAAAACAAACACAAAAAAACTCTTAATAGTAAGTAGACACCACATTCTTCTGTGTCTAGATAGTTG
Downstream sequence
AGTGGACAACTTGAGCTACCATAATGGGCAATTTCATCAAAGTAAACCAATTATGTAGTCAAAAAGCTGTATCAATAATGTAGCCAGAAGAGAGGATATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.