Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10008899
Fusion event
HBV-FAM3B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2265
Orient
+
Integrated sequence
TGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCT| |TTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGT
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
Start
End
42716556/41344629 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7c/Upstream/177000; hsa-mir-5692b/Downstream/402143;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/27471, chr21-CpG: 29/Downstream/75737
Upstream sequence
CAACTGTAAGTTACTAAACATTTTCTTTAAACTTCTCTAAAAGCTCTCTGGTCAGATTTTCAAAGGTACCTTGGGTTTTCGAGACTTTTGCGCGTGATTT
Downstream sequence
AGTCTAGGTTTGTATTTTAATGCATTTTAAGATTATATACTCAATTATTTTTACAAGTCTCACTTCACAGATTATTTGTGGTTCTAACAACAAATAAACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.