VISDB Viral Integration Site DataBase

VIS ID

TVIS10008901

Fusion event

HBV-MORC2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

766

Orient

-

Integrated sequence

TCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAA| |GTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTAC

Chromosome

chr22

Cytoband

q12.2

Reference genome

Start

End

31364542/30968556 (Hg38)

Orient

+

Location type

upstream

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-6515-3p ; hsa-mir-877-3p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-3675-5p

Nearest miRNA

hsa-mir-1286/Upstream/236915; hsa-let-7a-3/Downstream/191506;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/46054, chr22-CpG: 100/Downstream/22

Upstream sequence

CTCCCAAGTGAAAAAGCTCCTAGGCACTCACGATTTCTTTTTTCAAAGCCGGACCAAACCCAGTTCAGGGTGGTGGTCAGATTACCTCACACTTGGCCCA

Downstream sequence

CATAAACACCTCACAAATGACCCGCCCACAGCACCTCGGGCAGGCCGCGCCCCGCCCCCACGTCCCTCAGACAACAGCCTCAGCCTCCCAGGCCCTTCCC