Basic Information
VIS ID
TVIS10008910
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1613
Orient
-
Integrated sequence
ACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGG| |AGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAA
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
150443923/150726136 (Hg38)
End
150443923/150726136 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/16288230; hsa-mir-1224/Downstream/839740;
Nearest TSS
ENST00000440867/Upstream/18169; ENST00000461943/Downstream/35801;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/22044, chr3-CpG: 173/Downstream/35811
Nearby gene
ERICH6(-22181) ; SIAH2(+14987) ;
Upstream sequence
acATAATTTTCATTTGGATTTAGCCCAAAACTGAGTGAATTTGAATCATCCACTATAGGACCAAAGTATCTATATTTTTATAAACTTCAAATGTAATTTT
Downstream sequence
gggtctcgctatattgcccaggctggtcttgaactcctggcctcaagtgatccctgcctcagcctcccaaaatgttgggatgacaggtgggagccactgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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