Basic Information
VIS ID
TVIS10008913
Fusion event
HBV-LINC02015 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2002
Orient
+
Integrated sequence
ATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCG| |CCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGAC
Host Sequence
Chromosome
chr3
Cytoband
q26.32
Reference genome
GRCh37/hg19
Start
177549553/177831765 (Hg38)
End
177549553/177831765 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02015
Nearest miRNA
hsa-let-7g/Upstream/1316614; hsa-mir-1224/Downstream/6055035;
Nearest TSS
ENST00000440867/Upstream/3982; ENST00000450500/Downstream/103058;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/633699, chr3-CpG: 63/Downstream/1239752
Nearby gene
LINC00578(-79061) ; LINC01014(+587436) ;
Upstream sequence
AGGGAAACCGAGCTCCTACCACATTAGGCTAAGTGAATGGCTTTTCCTGCAACCAGGATGGTGGAGGAAGGAAAGAGTGGCAGGTGAAAGGTTTCCTATC
Downstream sequence
TGGGATACCTGCGCTGCCGATGGATTTGCCACATCTATTCTGTTCTCAGGTtgtatgttgtttgtgtgtgtgtgcttgtgtgtgtgcatgtgtgtgtgtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate