Basic Information
VIS ID
TVIS10008915
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2927
Orient
+
Integrated sequence
TCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAAC| |ACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGC
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
22930704/22889213 (Hg38)
End
22930704/22889213 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/2751572; hsa-let-7g/Downstream/2775660;
Nearest TSS
ENST00000440867/Upstream/515892; ENST00000628311/Downstream/313320;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/516339, chr3-CpG: 106/Downstream/313346
Nearby gene
ZNF385D(-1137888) ; UBE2E2(+314080) ;
Upstream sequence
GGAGAATAGCAGTTTTCACACCCCAGTTGCTAGCCTTGTTGCTGCAAGGAGCCCTCCCCTTCAATTGTGGGAGTATTTTGAAGGCTAAAGTAAGATACAG
Downstream sequence
CCAAATTGAAGGTCTCCCAAACTGGAAAGTTGTCTTCCCAGGTAGATGTAGTGAGCCTGACATTTTCCCACTTGTGTTCAACCCCGCTTTTGCAGATGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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