Basic Information
VIS ID
TVIS10008918
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
336
Orient
+
Integrated sequence
AATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCAC| |TCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCT
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
63704112/63718436 (Hg38)
End
63704112/63718436 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3100566; hsa-mir-12124/Downstream/3507028;
Nearest TSS
ENST00000440867/Upstream/65738; ENST00000647022/Downstream/100926;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/439907, chr3-CpG: 152/Downstream/144934
Nearby gene
SNTN(-53221) ; C3orf49(+100929) ;
Upstream sequence
agggttgatggttaaagcaaaaattataatactaactgatacagtttaaatatatgtacagaaaatatttaagtctattaaattataagcagagagaata
Downstream sequence
TACTTCATTTCAACTTGTTTATTTGATTTGTTTATTGTAACTCTTCTATTTAGATGAAATGGACCTTGCTAATATTCTTTATCCTTACATTTACCTATGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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