Basic Information
VIS ID
TVIS10008924
Fusion event
HBV-LOC102723576 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
-
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
100302437/99381280 (Hg38)
End
100302437/99381280 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC102723576
Nearest miRNA
hsa-mir-12113/Upstream/383820; hsa-mir-1243/Downstream/1859515;
Nearest TSS
ENST00000502981/Upstream/28253; ENST00000503257/Downstream/34594;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/292302, chr4-CpG: 40/Downstream/182290
Nearby gene
ADH1C(-28520) ; ADH7(+30981) ;
Upstream sequence
gttgattccattccatttcattccattccatttcactcgagttgattccattccattccattccattttattccattccattccatgaaattccattcca
Downstream sequence
atataattaattgttggaactggaacatttttgagactgaaaggtaagtcattaataattacTTTGTAATTATATTTTCAGCAAACCAAGACATATCATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate